Rounds of chemotherapy and a bone marrow transplant to treat leukemia had turned 51-year-old Greg Miller into a shadow of his former self.

The regimen worked. Miller was cancer-free. But he didn’t feel anything close to normal. An avid hunter and cement contractor, Miller was used to spending his days on the move. Unfortunately, the cumulative effect of his treatments had zapped his physical and mental strength.

“I couldn’t take stairs. I couldn’t step on a ladder,” he recalls. “I’d walk across grass that was uneven and I’d fall over.”

A swirling tornado of energy—that’s how ShawnMarie Prevost describes her 6-year-old daughter, Kailei.

“She sings, she hums, she moves,” ShawnMarie Prevost says. “She’s jacked. She’s just always, always going.”

Finding a viable treatment for Alzheimer’s disease (AD) continues to frustrate researchers around the world. The University of Minnesota Center for Drug Design’s Robert Vince, Ph.D., and Swati More, Ph.D., aren’t exempt.